Past catalysts on this ticker, reconciled against the announcement parse pipeline. Hover any row for the parsed outcome detail.
iPPS's own upcoming catalysts alongside class-defining historical readouts and upcoming primary completion dates in the same mechanism classes. Each event moves the broader thesis for iPPS. Showing past 6 months and next 12 months · 9 later hidden.
Same axes, same units. Discontinued and historical pivotal trials excluded; see Competitor Landscape below for the full set.
| Trial | Sponsor | Class | Phase / Line | Design | Primary endpoint | Dosing | Key eligibility | n |
|---|---|---|---|---|---|---|---|---|
| iPPS | Paradigm Biopharmaceuticals Limited | Polysaccharide therapeutic | Phase 3 | 0 | ||||
| Efficacy and Safety of Tongren-Dahuoluo Bolus in Patients with Knee Osteoarthritis | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | — |
Read-across commentary attached per trial. Phase ordering preserved within each group.
External analyst notes, journalism, and industry commentary cited with attribution.
"Sponsor guided" dates come from IR materials and earnings calls; hover for the cited source. "CT.gov proxy" dates fall back to the registry primary completion date — actual readouts typically follow by 3-6 months.
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| Platelet Rich Plasma Versus Corticosteroids in Hip Osteoarthritis Pain | LifeBridge Health | — | Phase 4 | — | — | — | — | — |
| Pain Perception During Intra-Articular Knee Joint Injection: What is the Effect of Needle Gauge and the Use of Ethyl Chloride? | University of California, Davis | — | Phase 4 | — | — | — | — | — |
| Optimal Articular Solutions With Intraosseous and Synovial Platelet-Rich Plasma | Universidade do Porto | — | Phase 4 | — | — | — | — | — |
| Corticosteroid Meniscectomy Randomized Trial | The Cleveland Clinic | — | Phase 4 | — | — | — | — | — |
| PRP for Glenohumeral Osteoarthritis | Hospital for Special Surgery, New York | — | Phase 4 | — | — | — | — | — |
| Comparison of Suzetrigine and Oxycodone for Postoperative Pain After Primary Total Knee Arthroplasty | University of Louisville | — | Phase 4 | — | — | — | — | — |
| Intraarticular Steroids, Saline and Occupational Therapy in People With CMC1 Osteoarthritis | Diakonhjemmet Hospital | — | Phase 4 | — | — | — | — | — |
| Subcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE-OA) | University of Melbourne | — | Phase 4 | — | — | — | — | — |
| Systemic Oral Glucocorticoids for the Treatment of Acute Osteoarthritis Pain in the Emergency Department | WellSpan Health | — | Phase 4 | — | — | — | — | — |
| Phase 4 Study of Laybon Tab. in Knee Osteoarthritis | Mather's Pharm. Co., Ltd. | — | Phase 4 | — | — | — | — | — |
| Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKA | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | — | Phase 4 | — | — | — | — | — |
| Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis | Northwestern University | — | Phase 4 | — | — | — | — | — |
| Study to Determine the Efficacy and Safety of TG-C in Subjects With Kellgren/Lawrence Grade 2 or 3 OA of the Knee | Kolon TissueGene, Inc. | — | Phase 3 | — | — | — | — | — |
| A Study to Determine the Safety and Efficacy of TG-C in Subjects With Kellgren and Lawrence Grade 2 or 3 OA of the Knee | Kolon TissueGene, Inc. | — | Phase 3 | — | — | — | — | — |
| Effects of Intra-articular Hypertonic Dextrose and Hyaluronic Acid on Primary Knee Osteoarthritis. | Bangladesh Medical University | — | Phase 3 | — | — | — | — | — |
| A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee | Eli Lilly and Company | — | Phase 3 | — | — | — | — | — |
| A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain | Novo Nordisk A/S | — | Phase 3 | — | — | — | — | — |
| Treatment Effects of Subcutaneous Injections of Pentosan Polysulfate Sodium vs Placebo in Participants With Knee OA Pain | Paradigm Biopharmaceuticals USA (INC) | — | PHASE2/PHASE3 | — | — | — | — | — |
| Autologous BMA vs Saline and LAM + LP-PRP vs Saline Evaluations in Knee OA | University Health Network, Toronto | — | PHASE2/PHASE3 | — | — | — | — | — |
| Phase II/III Randomized Trial of UC-MSC Secretome vs Sodium Hyaluronate in Knee Osteoarthritis | Universitas Sriwijaya | — | PHASE2/PHASE3 | — | — | — | — | — |
| An Open-Label, Double-Treatment Group Study to Evaluate the Efficacy and Safety of Human Allogeneic Bone-Marrow- Derived Mesenchymal Stromal Cell Product StromaForte Compared With Hyaluronic Acid for the Treatment of Knee Osteoarthritis | Cellcolabs Clinical SPV Limited | — | PHASE2/PHASE3 | — | — | — | — | — |
| Use of a Treated, Devitalized and Sterile Umbilical Cord Amniotic Membrane in the Treatment of PIP Joint Osteoarthritis | TBF Genie Tissulaire | — | Phase 2 | — | — | — | — | — |
| Antarctic Krill Oil for Knee Osteoarthritis Pain | Qilu Hospital of Shandong University | — | Phase 2 | — | — | — | — | — |
| The Safety/Efficacy of hUC Mesenchymal Stem Cells（19#iSCLife®-OA） Therapy for Patients With Osteoarthritis | Sclnow Biotechnology Co., Ltd. | — | Phase 2 | — | — | — | — | — |
| A Trial to Investigate the Safety and Efficacy of Intra-articular 4P004 Injection in Subjects With Knee Synovitis and Osteoarthritis | 4Moving Biotech | — | Phase 2 | — | — | — | — | — |
| Role of Methotrexate in Ultrasound Proven Synovitis in Primary Knee OA | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | — | Phase 2 | — | — | — | — | — |
| A Study to Assess the Efficacy and Safety of Vutiglabridin in Knee Osteoarthritis Patients | Glaceum | — | Phase 2 | — | — | — | — | — |
| Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis | University of Chicago | — | Phase 2 | — | — | — | — | — |
| Use of a Treated, Devitalized and Sterile Umbilical Cord Amniotic Membrane in the Treatment of STT Osteoarthritis | TBF Genie Tissulaire | — | Phase 2 | — | — | — | — | — |
| The Effect and Safety of Anti-inflammatories and Dextrose Prolotherapy Injections in Treating Knee Osteoarthritis | David Grant U.S. Air Force Medical Center | — | Phase 2 | — | — | — | — | — |
| 53-Week Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 With Mild to Severe Tibio-Femoral Osteoarthritis of the Knee | OrthoTrophix, Inc | — | Phase 2 | — | — | — | — | — |
| Use of a Treated, Devitalized and Sterile Umbilical Cord Amniotic Membrane in the Treatment of Trapeziometacarpal Osteoarthritis | TBF Genie Tissulaire | — | Phase 2 | — | — | — | — | — |
| Enhancing Modulation Effects of Baduanjin Through Neuromodulation for Knee OA | Massachusetts General Hospital | — | Phase 2 | — | — | — | — | — |
| An Study to Evaluate Safety and Tolerability of OA-SYS in Subjects With Moderate to Severe Osteoarthritis of the Knee Joint | Ageless Biotech, Inc. | — | Phase 2 | — | — | — | — | — |
| A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee | Pacira Pharmaceuticals, Inc | — | Phase 2 | — | — | — | — | — |
| A Phase 1/2a to Evaluate the Safety and Efficacy of Adipose Tissue Allograft (BRC-OA) in Patients With Osteoarthritis of the Knee | Britecyte | — | PHASE1/PHASE2 | — | — | — | — | — |
| COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty | Unity Health Toronto | — | PHASE1/PHASE2 | — | — | — | — | — |
| Recombinant Human Growth Hormone (rHGH) for Knee Osteoarthritis (KORR) | Dr. David Wasserstein | — | PHASE1/PHASE2 | — | — | — | — | — |
| Evaluation of Intra-articular CX-011 to Treat Moderate to Severe Pain From Knee Osteoarthritis | CarthroniX, Inc. | — | PHASE1/PHASE2 | — | — | — | — | — |